TRPA1 Mediates Aromatase Inhibitor–Evoked Pain by the Aromatase Substrate Androstenedione
نویسندگان
چکیده
منابع مشابه
Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1
Use of aromatase inhibitors (AIs), exemestane, letrozole and anastrozole, for breast cancer therapy is associated with severe pain symptoms, the underlying mechanism of which is unknown. The electrophilic nature of AIs suggests that they may target the transient receptor potential ankyrin 1 (TRPA1) channel, a major pathway in pain transmission and neurogenic inflammation. AIs evoke TRPA1-mediat...
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متن کاملAromatase is a cytochrome P-450 enzyme responsible for catalyzing the conversion of the androgens, androstenedione
catalyzing the conversion of the androgens, androstenedione (AD) and testosterone to the estrogens, estrone and estradiol, respectively. This process appears to proceed with three oxygenations of the androgens, each of which requires 1 mol of O2 and 1 mol of reduced nicotinamide adenine dinucleotide phosphate (NADPH). The 19-methyl group, as well as 1b and 2b-hydrogens, are eliminated in the th...
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The inhibitory effects of miconazole, an antimycotic agent, on aromatase activity for androstenedione in human placenta (105,000 X g pellet fraction) and ovary (800 X g supernatant fraction) were investigated. Various concentrations (0.1-100 microM) of miconazole, aminoglutethimide or delta 1-testololactone were added to the human placental preparation (1 mg protein) and then the mixture was in...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2016
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-16-1492